[Audio] YSPM’S Faculty of Pharmacy Seminar Topic :- Nucleophilic Substitution Reaction Sakshi Abhang & Pratik Bhosale First Year B-Pharm Yashoda Technical Campus , Satara.
[Audio] Nucleophilic Substitution Reaction :- A nucleophilic substitution reaction is a type of organic reaction in which an atom or group of atom is replaced from substrate by a nucleophile. − SN1 & SN2 reaction are nothing but simply a type of Nucleophilic Substitution Reaction. − The substitution can be occur either in one or two step. − The two step mechanism is known as SN1 reactions while one step mechanism is known SN1 reactions . − Nucleophilic substitution reaction mainly occurs in Alkyl Halides & Alcohols . Nucleophilic Substitution Reaction :- A nucleophilic substitution reaction is a type of organic reaction in which an atom or group of atom is replaced from substrate by a nucleophile. − SN1 & SN2 reaction are nothing but simply a type of Nucleophilic Substitution Reaction. − The substitution can be occur either in one or two step. − The two step mechanism is known as SN1 reactions while one step mechanism is known SN1 reactions . − Nucleophilic substitution reaction mainly occurs in Alkyl Halides & Alcohols ..
[Audio] SN1 Reaction SN2 Reaction Types Of Nucleophilic Substitution Reaction There are two types of nucleophilic substitution reaction First is sn1 reaction & second is sn2 reaction ..
[Audio] 1) SN1 Reaction :- − SN1 reaction stands for Unimolecular Nucleophilic Substitution Reaction . − It is a two step process . − The reaction follows first order of kinetics . − The reaction takes place in presence of weak base or weak nucleophile . − Order of reactivity = 1) SN1 Reaction :- − SN1 reaction stands for Unimolecular Nucleophilic Substitution Reaction . − It is a two step process . − The reaction follows first order of kinetics . − The reaction takes place in presence of weak base or weak nucleophile . − Order of reactivity is.
[Audio] Mechanism STEP 1 :- It is a slow & rate determining step in which carbocation is formed . STEP 2 :- Attack of nucleophile on carbocation to give product . Mechanism of sn1 reaction The reaction is carried out in 2 steps Step 1 Step 2.
[Audio] 2) SN2 Reaction :- − SN2 reaction stand for Bimolecular Nucleophilic Substitution Reaction . − It is a one step process . − The reaction follows second order kinetics . − Formation of transition state takes place . − Order of reactivity = 2) SN2 Reaction :- − SN2 reaction stand for Bimolecular Nucleophilic Substitution Reaction . − It is a one step process . − The reaction follows second order kinetics . − Formation of transition state takes place . − Order of reactivity is.
[Audio] Mechanism In SN2 reaction the nucleophile attacks on carbon atom of alkyl halide from backside which results in the formation of transition state & ultimately give product of opposite or inverted configuration to that of initial Alkyl Halide . Mechanism of sn2 reaction In SN2 reaction the nucleophile attacks on carbon atom of alkyl halide from backside which results in the formation of transition state & ultimately give product of opposite or inverted configuration to that of initial Alkyl Halide ..
[Audio] FACTORS AFFECTING ON SN1 & SN2 1) Nature Of Alkyl Halide :- Reactivity order of alkyl halides for SN1 is 3 > 2 > 1 . Reactivity order of alkyl halides for SN2 is 1 > 2 > 3 . 2) Nature Of Leaving Group :- More easily the leaving group removed from carbon atom faster will be the substitution reaction . R – I > R – Br > R – Cl > R – F 3) Nature Of Solvent :- Generally polar protic solvents are used for SN1 reaction . Polar aprotic solvents are used for SN2 reaction . – There are some factors that affects on sn1 & sn2 reaction . First one is Nature Of Alkyl Halide :- Reactivity order of alkyl halides for SN1 is 3 > 2 > 1 . Reactivity order of alkyl halides for SN2 is 1 > 2 > 3 . Second is Nature Of Leaving Group :- More easily the leaving group removed from carbon atom faster will be the substitution reaction . Third is Nature Of Solvent :- Generally polar protic solvents are used for SN1 reaction . Polar aprotic solvents are used for SN2 reaction ..
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