Mehak Zahra

Mehak Zahra. Evaluation of Phototoxic Potential of Green Synthesized Gold Nanoparticles Coated with liposome encapsulated Pheophorbide-a against Breast Cancer Cells.

[Audio] As reported by WHO (World Health Organization), millions of new breast cancer cases are diagnosed each year. Breast cancer is the secondary cause of death in 95% of world countries. In Africa 187 thousand women were detected with breast cancer in 2020, and this number is expected to reach 347 thousand by 2040, while 85.8 thousand people died from the disease in 2020, and 162 thousand will die by 2040.

[Audio] Some common conventional treatment methods are surgery, radiotherapy, chemotherapy, Hormonal therapy, Targeted therapy and Immunotherapy..

[Audio] Photodynamic therapy (PDT) is a developing procedure option in cancer therapy and certain non-malignant disorders. PDT is based on the administration of a non-reactive drug called photosensitizers (PSs), which accumulate in tumor tissues. PS molecules used specific wavelengths of light and become excited, resulting in the formation of ROS and the selective killing of tumor cells. The use of plant-based medicine may be an alternative or complementary therapeutic option for various types of cancer..

[Audio] Our current work in synthesis of green nanoparticles by using Dicoma Anomala and using an effective photosensitizer which doing nanoformulation and an express cancer cells. This study proposed a new therapeutical approach for the investigation of anticancer activities in breast cancer cell..

REFERENCES WHO (2023) WHO launches new roadmap on breast cancer . Available at: https:/ /www.who.int/news/item/03-02-2023-who-launches-new-roadmap-on-breast- cancer (Accessed: 8 March 2023). Chota , A., George, B.P. and Abrahamse, H. (2022) ‘In Vitro Cell Death Mechanisms Induced by Dicoma anomala Root Extract in Combination with ZnPcS4 Mediated- Photodynamic Therapy in A549 Lung Cancer Cells’, Cells , 11(20), p. 3288. Available at: https://doi.org/10.3390/cells11203288. Background Cancer image in slide 2: Available at: https://images.app.goo.gl/Ejt2Ze18zk3gxgvf7 (Accessed: 10 March 2023) Background image of plant in slide 4: Potential Treatment of Breast and Lung Cancer Using Dicoma anomala , an African Medicinal Plant Background Music: https://www.ashamaluevmusic.com/emotional-music Acknowledgments Thank you to my supervisor and Co-supervisor, Prof. Blassan George and Prof. Heidi Abrahamse for their support, and Laser Research Centre..