Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression.

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Summary. Major depressive disorders (MDD) Rho- gtpase and Rac1 Epigenetic regulation of Rac1 in chronically stressed mice and depressed individuals Therapeutic approaches for treating depression.

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Background information. Rho- gtp proteins regulate synaptic structure and depression-related behaviors Rac1 Nucleus accumbens of mice ( NAc ).

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Treating depression.

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Experimental set up. Diagram Description automatically generated.

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Chart Description automatically generated.

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Epigenetic mechanism. Chart, bar chart Description automatically generated.

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Epigenetic rescue of the Rac1 downregulation of susceptible mice.

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Regulation of RAC1 in subjects with MDD. Chart, scatter chart Description automatically generated.

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Epigenetic regulation of RAC1 mRNA expression in subjects with MDD..

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Rac1 controls stress-induced formation of excitatory spines.

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Identification of limitations as well as further studies needed.