Name: Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Uploaded: 2021-11-21
Duration: 9 min 32 s
Description: Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression.

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. 

Scene 1

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

Authors: Sam A Golden1, Daniel J Christoffel1, Mitra Heshmati1, Georgia E Hodes1, Jane Magida1,  Keithara  Davis1, Michael E Cahill1, Caroline Dias1, Efrain Ribeiro1, Jessica L Ables2, Pamela J Kennedy1, Alfred J Robison1, Javier Gonzalez-Maeso1, Rachael L Neve3, Gustavo Turecki4, Subroto Ghose5, Carol A Tamminga5 & Scott J Russo

https:// www.nature.com /articles/nm.3090#citeas

Summary. Major depressive disorders (MDD) Rho- gtpase and Rac1 Epigenetic regulation of Rac1 in chronically stressed mice and depressed individuals Therapeutic approaches for treating depression. 

Scene 2

Major depressive disorders (MDD) Rho- gtpase  and Rac1  Epigenetic regulation of Rac1 in chronically stressed mice and depressed individuals Therapeutic approaches for treating depression

Background information. Rho- gtp proteins regulate synaptic structure and depression-related behaviors Rac1 Nucleus accumbens of mice ( NAc ). 

Scene 3

Rho- gtp  proteins regulate synaptic structure and depression-related behaviors Rac1 Nucleus  accumbens  of mice ( NAc )

https:// en.wikipedia.org /wiki/ Nucleus_accumbens

https:// www.neuroskills.com /brain-injury/neuroplasticity/synaptogenesis/

Scene 4

Experimental set up. Diagram Description automatically generated. 

Scene 5

Diagram

Description automatically generated

Chart Description automatically generated. 

Scene 6

Chart

Description automatically generated

Epigenetic mechanism. Chart, bar chart Description automatically generated. 

Scene 7

Chart, bar chart

Description automatically generated

Epigenetic rescue of the Rac1 downregulation of susceptible mice. 

Scene 8

Epigenetic  rescue  of the Rac1 downregulation of susceptible mice

Regulation of RAC1 in subjects with MDD. Chart, scatter chart Description automatically generated. 

Scene 9

Chart, scatter chart

Description automatically generated

Epigenetic regulation of RAC1 mRNA expression in subjects with MDD.. 

Scene 10

Epigenetic regulation of  RAC1  mRNA expression in subjects with MDD.

A picture containing diagram

Description automatically generated

Rac1 controls stress-induced formation of excitatory spines. 

Scene 11

Rac1 controls stress-induced formation of excitatory spines

A picture containing company name

Description automatically generated

https:// www.researchgate.net /figure/Morphological-classification-of-dendritic-spines_fig3_11622109

Identification of limitations as well as further studies needed. 

Scene 12

Identification of limitations as well as further studies needed