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Conventin THE INTERNATIONAL TRUSTED BRAND. CONVENTIN CONVENTIN 400m? 300mg.

“Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.”.

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The FIRST Choice for NEUROPATHIC PAIN EVAPHARMA Securing Your Health Capsule Gabapentin 1 00, 300 & 400 mg CONVENTIN The First Choice for Neuropathic Pain.

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Neuropathic pain Guidelines. 2019. 0-6 Diabetes Care O'A'tttS STANDARDS OF MEDICAL CARE IN DIABETES—2019.

CJD O',ABETES CANADA F.ISF.VIER Contents lists available at ScienceDirect Canadian Journal of Diabetes journal homepage: www.canadianjournalofdiabetes.com 2018 Clinical Practice Guidelines.

Table 2. Selected neuropathic analgesic dosing regimens AGENT Anticonvulsants • Gabapentin • Pregabalin • Carbamazepine INITIAL DOSE 100-300 mg/d 25-150 mg/d 100 mg/d TITRATION Increase by 100-300 mg/d every wk Increase by 25-150 mgld every wk Increase by 100-200 mg/d every wk DOSE RANGE 300-1200 mg 3 times/d 150-300 mg twice daily 200-400 mg 3 times/d ADVERSE EFFECTS Drowsiness, dizziness, peripheral edema, visual blurring Drowsiness, dizziness, peripheral edema, visual blurring Drowsiness, dizziness, blurred vision, ataxia, headache, nausea, rash ADDITIONAL INFORMATION Dosage adjustments required in renal failure and in elderly patients Similar adjustments in renal failure Drug of first choice for idiopathic trigeminal neuralgia; as an enzyme inducer, it might interfere with activity of other drugs such as warfarin; monitoring of blood counts and liver function recommended.

Table 1 First-line drugs for painful diabetic neuropathy Medication TCAs Nortriptyline, desipramine, (amitriptyline, imipramine)* SNR1s Duloxetine Venlafaxine Gabapentinoids Gabapentin Pregabalin Source: Finnerup et al.45 Mechanism of Action Serotonin and norepinephrine reuptake inhibition, sodium channel block, NMDA- receptor antagonist Serotonin and norepinephrine reuptake inhibition Serotonin and norepinephrine reuptake inhibition A calcium-channel (126 ligand, which reduces release of presynaptic transmitters A calcium-channel ligand, which reduces release of presynaptic transmitters Target dose 25—150 mg, once a day or in two divided doses 60—120 mg, once a day 150—225 mg, once a day 1200—3600 mg, in three divided doses 300—600 mg, in two divided doses Abbreviations: SNRIs = serotonin-norepinephrine reuptake inhibitors; TCAs, tricyclic antidepressants. * Secondary amine TCAs (nortriptyline, desipramine) are preferred owing to better tolerability..

The FIRST Choice for NEUROPATHIC PAIN Diabetic peripheral neuropathy (1) 400/0 - 500/0 of Diabetic patients will develop sensorimotor polyneuropathy (1) Most common type is Distal Symmetrical Polyneuropathy (1) Symptoms of DPN# (1) Tingling & Numbness Plus Loss of protective sensation (1) • Sharp Shooting pain & Burning Conventin First Line Treatment in Diabetic Peripheral Neuropathy American Diabetes Association. Jan 2019 Canadian Diabetes Gabapentin 300 mg Twice daily or every bedtime (1) DPN€: Diabetic Peripheral Neuropathy.

Gabapentin 100, 300 & 400 mg Capsule CONVENTIN The First Choice for Neuropathic Pain • Conventin (Gabapentin) is recommended as first line treatment for Diabetic Peripheral Neuropathy according to ADA', CDA"& recent guidelines.(1Z3) • Conventin (Gabapentin) is recommended for treatment of chronic Neuropathic Pain by CPS# & NICE$ recent guidelines.(7'8) • Conventin (Gabapentin) relieves persistent Neuropathic Pain and improves sleep interference thus, improving patient quality of life.(12M3) e Conventin (Gabapentin) has a good safety profile as it by passes liver metabolism.(14).

Dose: e Conventin effective dose is from 900 mg to 1200 mg daily given in 3 divided doses. (15) • Conventin dose can be safely increased up to 3600 mg / day. (15) ADA' CPS' Amencan Diabetes Aæ•ociaton CanadJan Pain society CDA" Canaman NICEST National inst'tute for Health and Care Excellence IASPT International tor the Study Ot Pan.