The novel breast cancer treatment
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PATENTED INVENTION OF FLAVONOID DIMERS FOR TREATING CANCERS OH O FD-9d 0-61 0-18 FM-04 Ac12Az9 Ac13Az9 Apigenin in celery (antioxidant, anticancer) HO 2006 2022 OH Monomer Dimer Modulator to reverse drug resistance Oral cancer drug Brain cancer drug Reverse the drug resistance of breast cancer stem cells (bCSCs) Outputs: 5 Patents 1 Licensing 4 Awards 19 Papers Patented technology.
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[Ac15(Az2)2+ cancer drug] reduces tumor volume by 90% in animal study Breast Cancer Animal Model Tumor volume % change Tumor excised 300 200 o 100 o 5) -100 Injections Solvent control Cancer drug + Cancer drug Solvent Ac15(Az 2 Cancer drug Cancer drug 4 8 12 16 20 Days post treatments t tt Combination of Ac15(Az2)2 and cancer drug Novel, potent and safe 2.
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INNOVATION / IMPORTANCE OF (SO Regular cancer cell O Cancer stem cell (CSC) bCSCs PRDXI OUR INVENTION Flavonoid dimer (FD) Dead cancer cell PRDXI Chemo ROS (ROS scavenger) PRDXI ROS generated PRDXI ROS generated bCSCs unresponsive PRDXI RDX Chemo ROS ROS No FDA-approved anti-CSC treatment bCSCs responsive = Peroxiredoxin 1.