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B,' YOTEKNOL OJI BY NATURE POWERED BY s C' E: NGE

BUGAMED Biotechnology has been transforming organic wastes into the future with its patented technology since 2017 with the slogan "Inspired by Nature, Powered by Science" Bugamed produce "Medical Collagen", which is one of the important raw materials of the Biotechnology/Medicine/Medical Device Sector. It has developed 5 products since 2017 and has 2 patent applications. Our scientific team can collaborate with your product design team to create functional collagen such as lyophilized, solutions with various concentrations which will customize for your work.

BUGAMED BİYOTEKNOLOJİ SAN. VE TİC. A.Ş.

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Bugamed Quality Policy BUGAMED Biotechnology produces critical raw materials in the pharmaceutical and medical device industry, especially medical quality collagen. Our organization implements and develops ISO 13485 Quality Management System, National and International Legal Terms, Legislation and Medical Devices Directive (MDD 93/42/EEC and 2017/745 MDR), TS EN ISO 22716:2013 Cosmetics-Good Manufacturing Practices (GMP)-Guide to Good Manufacturing Practices as a quality policy. BUGAMED Biotechnology aims to develop high-tech products by carrying out scientific studies in the field of biotechnology and to meet the needs of people in the field of biotechnology with domestic, advanced technology for a qualified life.

Bugamed Biotechnology has won various awards since established. Such as: for “Health Initiative of the Year Awards - R&D / Innovation Application of the Year” and “Seal of Excellence” award from European Commission Horizon 2020

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Core Technologies Biomaterials Scaffold ( foam , film, fibrous mat) preparation from biodegradable polymers (PHBV, PLA, PLGA, PCL, PGS, collagen, hyaluronic acid , fibrin, alginate , gelatin , fibroin , sericin, chitosan ) using macro / micro - and nanofabrication techniques and electrospinning . Preparation of natural scaffolds through decellularization of tissues . Cell Culture Mesenchymal Stem Cell Research (Bone marrow , adipose tissue , Wharton’s Jelly , umbilical cord blood , peripheral blood , dental pulp , skeletal muscle - isolation , characterization , growth and differentiation to mesodermal cell lineages ). Tissue Engineering 2D and 3D patterned scaffolds , protein immobilization to the scaffolds , biomimetic approach . Biodegradable Polymer Processing for Tissue Engineering Applications. Bone tissue engineering , cartilage tissue engineering , adipose tissue engineering , skeletal muscle and myocardial tissue engineering . Micro- vascularised 3D Construct Preparation . In vitro tissue model preparation through co-culture of different cell types .

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ABOUT COLLAGEN Collagen is the most important structural protein in the human body. Collagen fibers found in bones, tendons, skin, joint cartilage, ligaments and muscles make up one third of our entire protein content. It allows the cells to adhere to the extracellular matrix surface with its adhesive feature. Collagen fibers strengthen the connective tissue and provide structural support and regeneration of cells (skin, skin, etc.), as well as provide flexibility and frequency. Bovine tendon-derived Type I collagen can be prepared as a clear gel that provides a 3-dimensional matrix or surface designed to heal wounds, burns, or damaged tissues coated on tissue culture plates as a substrate for culturing primary cells such as keratinocytes and hepatocytes. For such medical applications, implants, heart valves, and blood vessels are produced.

COLLAGEN APPLICATIONS

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Ap#arance Odor Extraction Sterilization method Water solubility Storage Shelf life Solution shelf life Collagen purity- Silver staining Source I Conagen I Physical state: Lyophilized Color: white No data available Enzymatic - Atelocollagen Filtration 3 (in 0,01 M HCI) Store at •20 oc. After making the solution, store it at 2-10 oc At least 6 rnonths from date At least 3 months after turning it into a solution -93.9 Bovine Tendon Appearance Odor Extraction method Sterilization Water solubility Storage temperature Shelf life Solution shelf life Collagen purity- Silver staining Physical state: Lyophilizea Color: white No data available Enzymatic - Fibrillar collagen Filtration 3 mgml (in 0.01 M HCI) Store at •20 oc. After making the solution, store it at 2-10 oc. At least 6 months from date At least 3 months after turning it into a solution. -98.9 Appearance Odor methtxi Sterilization methcxi Water solubility Storage temperature pH Shelf life Collagen purity- Silver staining Packaging quantity Solution No data available Enzymatic • Atelocollagen Filtration 3 mg / (in 0.01 M HCI) 2-100C 1.8-2.1 At least 6 months from production date -98.9 100 ml- IOOOml Electrophoretic property Blue Characteristic Electrophoretic property -Coomassie Blue Characteristic Electrophoretic pro#rty G)massie Blue Characteristic Endotoxin/LAL Source <10Ewml Bovine Tendon Endotoxin/LAL Sou rce 10 EU/ml Bovine Tendon Endotoxin/LAL <10EU/ml

PRODUCT PORTFOLIO

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PRODUCT PORTFOLIO

Appearance Extraction Sterilization Water wlubility quantity Storage temgprature Shelf life %lution No data available Acidic - Telcxollagen Filtration 1.8-2.1 3 (in 0.01 N HCI) 1m - ICmml 2-10•c At least 6 from prcxfuction date Appearance Odor Packaging quantity Storage Shelf life Disc diameter Disc thickness Pore diameter Six)nge form No data available 5 or 25 pieces Room At least 6 months from production date 7.5 mm veya —15.6 mm 1.5 mm veya 3 mm Average microns Odor Packaging quantity Storage temperature Shelf life pH Concentration Solution, slightly cloudy No data available 20 mL ooec At least 6 months from date 24-4.5 —50 mg/mL Neutralizing buffer solution storage conditions Room Collagen purity• Silver staining —98.9 Fibroin purity- SDS Page electrophoresis Characteristic Collagen purity- Silver staining Electrophoretic prockTty -Coomassie Blue Endotoxin/LAL Source -98.9 €10 EU,'ml Bovine Tendon Endotoxin/LAL Collagen source Sterilization method < 10 EU/ml Pure Type I collagen from Bovine Terminal Molecular Weight (kDa) Average mol. weight IW kDa Bombyx mori silkworm

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COLLAGEN SOURCED PRODUCTS BUGA- CoL TYPE I COLLAGEN from bovine tendon BUGA-TELOCOLLAGEN from bovine tendon BUGA- CoL COLLAGEN from bovine flexor tendon BUGA- CoL TYPE I COLLAGEN SOLUTIONS 3 mg/mL, sterile filtreted , BSE free BUGA- CoL TYPE I COLLAGEN SOLUTIONS 6 mg/mL, sterile filtreted , BSE free BUGA- CoL COLLAGEN SOLUTIONS 10 mg/mL, sterile filtreted , BSE free BUGA- TELOCOLLAGEN SOLUTIONS 3 mg/mL, sterile filtreted , BSE free BUGA- TELOCOLLAGEN SOLUTIONS 6 mg/mL, sterile filtreted , BSE free BUGA- TELOCOLLAGEN SOLUTIONS 10 mg/mL, sterile filtreted , BSE free BUGA- CoL TYPE I COLLAGEN SOLUTIONS for Cell Culture

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THANK YOU FOR INTEREST