Scene 1 (0s)
Hémostase.
Scene 2 (5s)
Hémostase.
Scene 3 (10s)
Hémostase Hémostase : cessation de l’écoulement du sang (4-3) Phases : 1e Phase : - Constriction – diminue le flot sanguin ii) 2 aPhase : - Thrombus blanc ii) 2b Phase: - Thrombus rouge-caillot iv) 3e Phase: - Dissolution.
Scene 4 (22s)
Coagulation.
Scene 5 (28s)
Coagulation.
Scene 6 (33s)
Platelet p I a tele t Red cell Bro n bloc) d •vessel II F i bri.
Scene 7 (40s)
Clotting chain reaction in blood: Calcium and Blood clot Thrombrin Platelet Red blood cell Fibrin Fibrin "net" formed Blood clot Trigger other factors" Platelets become "sticky" medmowe com.
Scene 8 (48s)
Norrnal Bleeding starts 2— Vessels constrict 3- Platelet plug Fibrin clot Bleeding Disorder -1 Bleeding starts 2— Vessels constrict 3— Incor-nplete platelet plug. confined bleed ing 4— and/or delayed fort-nation of fibrin clot. continued bleeding.
Scene 9 (1m 0s)
BALANCE OF HEMOSTASIS Clotting Activators Vessels Platelets Coagulatton Fibrinolysis Bleeding &.Jnhib1tors. ;.
Scene 10 (1m 7s)
PLASMA/SERUM.
Scene 11 (1m 13s)
PLASMA/SERUM.
Scene 12 (1m 18s)
Groupe Sanguin-Microbiome Human Microbes: The Power Within: pp 127.
Scene 13 (1m 25s)
Coagulation Sanguine.
Scene 14 (1m 31s)
La formation du caillot • Activation du prothrombine en thrombine • Fibrinogène (Facteur I) se transforme en caillot sanguine avec l’aide de la thrombine • Vitamine K --> impliquée dans la production de la prothrombine, produit par des bactéries dans l’intestin --> en métabolisant les plantes • Antagoniste de la vitamine K --> Dicoumarol (hémorragie) --> feuille de trèfle • Prothrombine (Facteur II) --> (activé par Ca+ et phospholipides) Thrombine (Facteur IIa) • Thrombine --> serine protéase qui hydrolyse le fibrinogène Thrombine forme les caillots • Plasmine dissous les caillots • Héparine --> inhibe Thrombine • Streptokinase --> active la plasmine.
Scene 15 (1m 55s)
inr.ry or remmral Uood trom Pre!imnary steps ciotmg ProttuocrWin Prothromtires.e Fibrinoyen Thrombin Forti tryeais Bloc.d cens p'astna.
Scene 16 (2m 3s)
Facteurs Sanguins • Il existe XIII facteurs, si le facteur VIII est absent- hémophilie • Facteur I : Fibrinogène • Facteur II : Thrombine (signaux internes et externes) • Caillot sanguin est compose par des corpuscules et des fibrines former comme un filet • Plasmine dissout le caillot • Si des caillots se forment, on a la thrombose • Si des caillots ne se forment pas, on a l’hémophilie •.
Scene 17 (2m 21s)
EXTRINSIC PATHWAY Damage to tissues [leaks) Tissue Factor Ill (TF,) 2. Clotting Factor VII (CF7) (combine to form] Factor VII—Tissue Factor Complex (TF-F7) [activates) INTRINSIC PATHWAY Damage to endothelium [activates] Factor XII (Fu) Platelet Factor Ill (Ph) Clotting Factors VIII & IX (CFS, CF9) [combine to forml Factor X-Activator Complex (activates) Prothrombinase (Prothrombin Activator) Prothrombin Thrombin Fibrinogen Fibrin.
Scene 18 (2m 34s)
Major Components of Hemostasis Vascular Injury Vasoconstriction Collagen Platelet Activation vWF, fibrinogen Platele Plüg Primary Hemostasis Tissue factor Coagulation Cascade Thrombin Fibrin Antithrombotic Control Mechanisms Blood Clot Plasmin Fibrinolysis & Clot Degradation Secondary Hemostasis.