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Mind Map (Course Overview). Alzheimer. Macintosh HD:Users:ben:Desktop:.
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Glial cell proliferation Neuroprotection copper ions redox to reduce ROS Neurite outgrowth myelination.
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A) PrP o/o mice show alterations in synaptic processes (Collinge et al., 1994).
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Bild 1. D). Proposed Physiological Role of PrP.
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PrP c -knock-out mice are resistant towards a scrapie infection (Bueler et al., 1993).
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IMG0016 pct 00010F73 Dokumente B3438E48.
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IMG0017 pct 00010F73 Dokumente B3438E48. IMG0018 pct 00010F73 Dokumente B3438E48.
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Retroviruses act as Rickshaws for prions. IMG0017 pct 00010F73 Dokumente B3438E48.
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IMG0021 pct 00010F73 Dokumente B3438E48. PrP Sc binds to PrP c in a heterodimer and forces PrP c to undergo a structural change, resulting in the formation of a new PrP Sc molecule. In a rolling circle like mechanisms, PrP Sc might dissociate from the dimer complex and converts more PrP c molecules to PrP Sc ..
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Conversion of PrP c to PrP Sc is similar to the process of permanent waves (straight hair curly/waves) . The latter however, includes breakage and re-unification of disulfide bridges, whereas the conversion of PrP c into PrP Sc encompasses conversions of alpha helices into beta-sheets. Both processes are irreversible!.
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states that PrP Sc must contain a small amount of host derived nucleic acid co-prion or molecule that specifies prions infectivity Co-prion is encased in the infectious scrapie prion Scrapie prion generated in manner similar to heterodimer hypothesis.
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IMG0024 pct 00038D3B Dokumente B1BBC634. Nucleation dependent polymerization model (Crystal Seed).
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The following statement/s are correct. A) Prion proteins contain 3 alpha helices and 1 antiparallel beta sheet. B) prions can be inactivated by standard autoclaving, heat (up to 600 °C ) and treatment with 2 N HCl C) Prion protein is contributing to synaptic transmission, normal circadian activity and long-term memory and is required to develop a prion disorder D) Retroviruses act as rickshaws for prion release E) Prions are not viruses and they replicate in a process similar to permanent wave production.
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Is BSE transmissible to humans?.
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IMG0036 pct 00038D3B Dokumente B1BBC634. 1.) Macaques inoculated with BSE in the brain or feeded with BSE show the same plaque morphology as vCJD patients.