KANAMYCIN

KANAMYCIN. An Aminoglycoside Antibiotic Presented by: HARISH S JENITHA V MADHAN V SREETHA R PHARMACEUTICAL TECHNOLOGY / MEC.

CONTENTS. INTRODUCTION CLASSIFICATION MECHANISM OF ACTION USES DOSAGE & ADMINISTRATION SIDE EFFECTS PRECAUTION ADVANTAGES DISADVANTAGES CONCLUSION.

[Audio] The antibiotic kanamycin is effective against a wide range of bacteria including those causing tuberculosis and pneumonia. It works by inhibiting protein synthesis in bacteria, thereby preventing them from multiplying. Kanamycin is also known for its ability to inhibit the growth of certain fungi and protozoa. Its effectiveness has been demonstrated in treating various types of bacterial infections such as septicemia, meningitis, and osteomyelitis. Kanamycin is often used in combination with other antibiotics to enhance its efficacy..

[Audio] The classification of kanamycin as an aminoglycoside antibiotic reveals its mechanism of action and spectrum of activity. Kanamycin inhibits protein synthesis in bacteria by binding to their ribosomes. Its broad-spectrum activity makes it effective against many Gram-negative bacteria that cause various diseases. However, its effectiveness is limited against Gram-positive bacteria and certain other types of pathogens. The classification of kanamycin also warns of its potential side effects, such as damage to the inner ear and kidneys. Overall, the classification of kanamycin provides useful information about its properties and uses..

MECHANISM OF ACTION. Binds to 30S ribosomal subunit. Inhibits protein synthesis. Causes formation of faulty proteins. Leads to bacterial cell death (bactericidal)..

USES OF KANAMYCIN. Treatment of tuberculosis (TB). Serious Gram-negative infections. Septicemia. Used when other antibiotics fail..

DOSAGE AND ADMINISTRATION. Given by intramuscular (IM) or intravenous (IV) injection Not given orally (poor absorption) Dosage depends on: 1. Age 2. Body weight 3. Kidney function..

SIDE EFFECTS. Ototoxicity (hearing loss). Nephrotoxicity (kidney damage). Dizziness. Nausea and vomiting..

PRODUCTION PROCESS. Microorganism: Produced by fermentation using Streptomyces kanamyceticus. Fermentation: Submerged aerobic fermentation in a nutrient medium (carbon + nitrogen sources) at controlled pH and temperature. Recovery: Filtration to remove biomass. Purification: Ion-exchange chromatography and crystallization. Final product: Dried and formulated as kanamycin sulfate..

[Audio] Kanamycin is an antibiotic belonging to the class of aminoglycosides. It has several advantages over other antibiotics. Firstly, it is effective against resistant bacteria. This means that it can target bacteria that have developed resistance to other antibiotics. Secondly, kanamycin has rapid bactericidal action. This implies that it can quickly kill bacteria, making it useful for treating infections. Finally, kanamycin is useful in severe infections. This makes it a valuable option for treating serious bacterial infections..

[Audio] The disadvantages of Kanamycin include causes of hearing loss, kidney toxicity, and not being suitable for treating mild infections. These side effects can have serious consequences on human health. The potential for ototoxicity and nephrotoxicity makes it essential to use this antibiotic with caution and under medical supervision. Furthermore, its inability to treat mild infections may limit its effectiveness in certain situations. This highlights the importance of careful consideration when prescribing Kanamycin..

[Audio] The antibiotic kanamycin is used to treat bacterial infections caused by certain types of bacteria that are resistant to other antibiotics. It is typically administered via injection into the muscle or vein, and it can cause side effects such as hearing loss and kidney damage. The drug is usually reserved for treating severe infections that do not respond well to other treatments..

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