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[Audio] How I cure a cold sore in 2 days? Disclaimer is that the information provided here is for educational or informational purposes only and should not be considered a substitute for professional medical advice or consultation with healthcare professionals. You expressly acknowledge and agree that using information is at your own risk. This 3-step natural home remedy helped to clear the cold sore on my lower lip in 48 hours. Step 1: Apply Nettle Leaf Extract on the blister every 4 hours with a Q tip or cotton 4 times a day. It does sting. Step 2: Apply 20 percent zinc oxide cream on the blister every 4 hours 4 times a day. (alternate every 2nd hour from step1) Step 3: Take one tablet of L-Lysine 1000 mg twice a day with a meal or food..