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JSS oss acaoeny 2021 NAAC nirf NATIONAL INSTffUTlONA RANKING FRAMEWORK ASIAN UNIVERSITY RANKINGS WORLD UNIVERSITY 2022 351- 400 ARIIA A•r.u OF ON r•NOVAT'0N ACHIEVEMENTS 2020 A + 34th 291-300 Band A in INDIA Rank Band 6 to 25 JSS Medical College - 24th*JSS Dental College & Hospital -12th* JSS College of Pharmacy, Mysuru - 9th *JSS College of Pharmacy, Ooty - 7th.

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JSS Academy of Higher Education & Research | Faculty of Pharmacy.

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Dr. Md. Afzal Azam , M.Pharm ., Ph.D., Professor & Head Academic & Research experience: 30 yrs.

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Department of Pharmaceutical Chemistry JSS College of Pharmacy, Ooty 4 x 0 Our Expertise Target based drug design In silico virtual screening Green synthesis of small heterocycnc molecules Custom synthesis Impurity synthesis Synthetic route development of AP HEADING HERE CONTACTS Dr. Md. Afzal Azam (9486687029) Dr. R. Kalirajan (9994098087) Dr. S. Jubie (8667452891) Dr. B. Gowramma (7904912372) Dr. S. Gomathy (9486433876) Dr. G. Swamynathan (9790095279) Dr_ J. Srikanth (9524441948) E-mail: chemistryjsscpooty@gmail.com Hit to lead and lead optimization Anticancer agents Antibacterial agents Neuroprotective agents Natural product research YOUR PARTNER FOR SUCCESS.

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FACULTY PRIMARY RESEARCH AREAS Structure based drug design and heterocyclic synthesis of antibacterial & anticancer agents. Target based polymeric drug conjugate design and peptide synthesis. S ynthesis of novel fatty acid analogues for cancer therapy and immunomodulatory metal conjugates. Computational approaches and synthesis of heterocyclics targeting Parkinson’s disease. In silico design, synthesis of novel molecules as Neuroprotective agents. Isolation, characterization and evaluation of bio actives as Neuroprotective agents. Structure based design of small molecules as antitubercular agents..

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Total No. of PhD awarded : 48 Total No. of PhD On-going : 26.

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10 0 18. TOXIC REACTION ROOM.

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• •Protein Modeling and Department o' Phormr.. uSS.

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Chandrasekar MJN, Kumar SM, Manikandan D, Nanjan MJ. Isolation and evaluation of a polysaccharide from Prunus amygdalus as a carrier for transbuccosal delivery of Losartan potassium. International Journal of Biological Macromolecules . 2011: 48 (5); 773-778 [IF: 6.953] Kalirajan R, Kulshrestha V, Sankar S, Jubie S. Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors. European Journal of Medicinal Chemistry . 2012: 56; 217-224 [IF: 6.51] Jubie S, Ramesh PN, Dhanabal P, Kalirajan R, Muruganantham N, Shanish Antony A. Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. European Journal of Medicinal Chemistry . 2012: 54; 931-935 [IF: 6.51] Azam MA, Thathan J, Jubie S. Dual targeting DNA gyrase B ( GyrB ) and topoisomerse IV ( ParE ) inhibitors: A review. Bioorganic Chemistry . 2015: 62; 27-33 [IF: 5.27] Jameera Begam A, Jubie S, Nanjan MJ. Estrogen receptor agonists/antagonists in breast cancer therapy: A critical review. Bioorganic Chemistry . 2017: 71; 257-274 [IF: 5.27].

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M CSIR NCI Role o A1 in SDGs and+lealth (Application of A1 in Drug Discovery) JSS COLLEGE OF PHARMACY, Adjuncccacuö / al Webinar S„eries SPEAKER Dr. M. Karthikeyan Senior Principal Scientist CSIR-NationaI Chemical Laboratory Pune SUSTAINABLE DEVELOPMENT 17 GOALS TO TRANSFORM OUR WORLD 10 •u 17 CPO or M Karthike n NCL Zune Dr. Gomathy Su... % Dr. Gomathy Subramanian shalini shalini.

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Manal M, Chandrasekar MJN, Gomathi Priya J, Nanjan MJ. Inhibitors of histone deacetylase as antitumor agents: A critical review. Bioorganic Chemistry. 2016: 67; 18-42 [IF: 5.27] Nanjan MJ, Mohammed M, Prashantha Kumar BR, Chandrasekar MJN. Thiazolidinediones as antidiabetic agents: A critical review. Bioorganic Chemistry. 2018: 77; 548-567 [IF: 5.27] Gomathi Priya Jeyapal , Rajendiran Krishnasamy , Carolyn K Suzuki, Sundararajan Venkatesh , MJN Chandrasekar . In- silico design and synthesis of N9-substituted β- Carbolines as PLK-1inhibitors and their in-vitro/in-vivo tumor suppressing evaluation. Bioorganic Chemistry. 2019: 88 [IF: 5.27] Santhosh S B, Mohamed Sheik Tharik A, Balakrishnan R M, Muruganandam N, Susitra Manjari M, Chandrasekar MJN. Coronavirus disease- COVID-19: New perceptives towards epidemic to pandemic. Journal of Drug Targeting. 2020: 28(7-8); 755-759 [IF: 5.121] Azam MA, Jayaram U. Inhibitors of alanine racemase enzyme: A review. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016: 31 (4); 517-526 [IF: 5.051].

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1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020.

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e$€s&soe Dec nary Convocation nkaia ove. J SS Aca e Sri S N zd$ddo± '$..ss.s-•egd Twelfth 17 De . • Friday 4.00 PM sri Suttor Math..

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S. No. Name of the Principle Investigator Title of the Project Funding agency Amount (In Lakhs) Duration 1 Dr.GVS . Ramasarma R& D Project Substantial grants AICTE 3.00 1997-98 2 Dr.GVS. Ramasarma MODROBS AICTE 3.00 1998-99 3 Dr. S.Badami Screening and evaluation of anticancer potentials from herbal resources of the Nilgiris DBT 16.15 2003-06 4 Dr. S. Sankar EDC Scheme -Medical Transcription programme AICTE 8.00 2006-09 5 Dr. MJN. Chandrasekar Targeting anticancer macromolecular prodrugs DST 6.26 2006-09 6 Dr. S. Sankar Isolation, screening and characterization of the fertility regulating phyto -constituents present in the traditional plants of the Nilgiris, Derris brevipes , Duriozibenthinus CSIR 11.80 2009-12 7 Dr. BR. Prasantha Kumar Computer aided design, synthesis and anti- hyperglycaemic activity of some novel selective glitazones as possible insulin sensitizers AICTE-RPS 7.50 2010-12 8 Dr. S. Sankar Synthesis characterization and evaluation of their cytotoxic and antimicrobial activities of some novel heterocyclic compounds AICTE-RPS 14.00 2011-13 9 Dr. MJN. Chandrasekar Design, synthesis and evaluation of some novel dipeptidylpeptidase IV inhibitors as antidiabetic agents UGC 10.86 2011-14 10 Dr. Mohammed Afzal Azam Phosphodiesterase inhibitors. Design, synthesis and QSAR studies of PDE 4B-inhibitory benzazoles with anti-inflammatory and bronchodilatory activity DST- SERB 33.58 2013-17.

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4.04. -'NIIioøi8.

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S. No. Name of the Principle Investigator Title of the Project Funding agency Amount (In Lakhs) Duration 11 Dr. MJN. Chandrasekar Virtual high throughput screening ( vHTS ), design,synthesis , invitro/in vivo evaluation and 3D-QSAR investigations of some novel ᵟ - carboline and carbazole lead molecules as antineoplastic agents DBT 47.66 2014-17 12 Mrs. GomathiPriya. J (PI: Dr. MJN. Chandrasekar) Design virtual screening,synthesis and biological evaluation of Carboline derivatives against antitumor targets. DST-WOS-A (Women Scientist) 20.40 2015-18 13 Mrs. Ms. Manal M. (PI: Dr. MJN. Chandrasekar) In silico design of Novel Heterocycles as histone deacetylase inhibitors synthesis and their evaluation for antineoplastic activity DST-WOS-A (Women Scientist) 21.00 2015-18 14 Ms. Nivishna V. (PI: Dr. MJN. Chandrasekar) Targeting poly Lmalic acidDoxorubicin nanoparticles to liver cancer DST-WOS-A (Women Scientist) 18.60 2015-18 15 Dr. MJN. Chandrasekar Development and Evaluation of Plant based Radioprotective Agents DRDO 17.096 2015-19 16 Dr. MJN. Chandrasekar Phase transition mediated targeting of thermosensitive polymerdrug conjugates to human ovarian tumours. DBT NE 28.33 2016-19 17 Dr. Mohammed Afzal Azam In Silico Design Synthesis and Evaluation of MurD and MurE Ligase Inhibitors Against Methicillin Resistant Staphylococcus aureus DST- SERB 42.591 2017-20 18 Dr. S. Jubie Structure based in-silico docking and rational design of fatty acid synthasethioesterase domain inhibitors as potential anticancer lead compounds. JSSAHER 0.40 2017-20 19 Dr. B. Gowramma Design synthesis and evaluation of novel 1,3,4thiadiazole derivatives as gamma secretase inhibitors for the treatment of breast cancer. JSSAHER 0.50 2017-20 20 Dr. S. Gomathy Design synthesis of novel fourthiazolidinone derivatives and antiParkinsons agents. JSSAHER 0.50 2017-20.

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