Name: CELL SWELLING AND INTRACELLULAR ACCUMULATION
Uploaded: 2024-05-06
Duration: 2 min 15 s
Description: [image] A petri dish with some transparent capsules.

[image] A petri dish with some transparent capsules. 

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[image] A petri dish with some transparent capsules

CELL SWELLING 
AND 
INTRACELLULAR ACCUMULATION

CONTENTS. CONTENTS. 2. Exploring cell swelling Intracellular accumulation. 

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Exploring cell swelling Intracellular accumulation

CELL SWELLING. CELL SWELLING. 3. Cell swelling, also known as hydropic degeneration, is the earliest and most universal indicator of potentially reversible cellular injury. Cell swelling occurs when the cell loses its ability to precisely control the influx of sodium (Na+) ions and water and efflux of potassium (K+) ions to the cytosol.. 

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Cell swelling, also known as hydropic degeneration, is the earliest and most universal indicator of potentially reversible cellular injury.  Cell swelling occurs when the cell loses its ability to precisely control the influx of sodium (Na+) ions and water and efflux of potassium (K+) ions to the cytosol.

CELL SWELLING:
Mechanisms & triggers. Sodium and water influx. 

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Cell swelling occurs when the precise control of sodium (Na+) ions and water influx is disrupted, leading to an imbalance that results in cellular edema.

The efflux of potassium (K+) ions plays a crucial role in maintaining cellular homeostasis. Disruptions in this process can contribute to cell swelling.

Cell injury can provoke various responses, including vascular, inflammatory, and immune-mediated reactions, exacerbating the effects of cell swelling.

Consequences of Cell Swelling. Hyperosmolarity and Water Uptake. 

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Intracellular hyperosmolarity leads to excessive water accumulation, resulting in cell swelling, protruding pockets, and eventual lysis.

Under a microscope, cell swelling makes the cells appear cloudy or pale as the accumulation of water dilutes the organelles within the cell.

Not all cells swell at the same rate, with variations in the rate of permeability leading to differential responses to cell swelling.

[image] Mitochondria Behind Blood Cell Formation News Center

INTRACELLULAR ACCUMULATION. INTRACELLULAR ACCUMULATION. 

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Intracellular accumulation refers to the buildup of substances within a cell beyond normal levels, often due to impaired metabolism, transport, or excretion. This can include lipids, proteins, carbohydrates, pigments, or minerals. Such accumulation can lead to cellular dysfunction and damage, contributing to various diseases like fatty liver disease, lysosomal storage disorders, and protein aggregation diseases like Alzheimer's. Understanding the mechanisms underlying intracellular accumulation is crucial for developing targeted therapies and interventions to mitigate its effects.

Types of Intracellular Accumulation. Lipid Accumulation. 

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Investigating the accumulation of lipids within cells and its association with metabolic disorders and organ dysfunction.

Exploring the formation of protein aggregates within cells, leading to impaired cellular function and potential pathological consequences.

Understanding the aberrant accumulation of glycogen within cells and its implications for metabolic health and cellular homeostasis.

[image] White DNA structure. Thank you. [image] Bacteria cultured in a petri dish for a laboratory or a scientific investigation. 

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[image] Bacteria cultured in a petri dish for a laboratory or a scientific investigation

CELL SWELLING AND INTRACELLULAR ACCUMULATION

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