PowerPoint Presentation

[Audio] Active transport mechanisms involve the use of a carrier molecule to move solutes across a membrane without the expenditure of energy. These mechanisms utilize an energy source such as A-T-P and have a carrier protein to transfer the molecules. Furthermore they are able to move molecules against their concentration gradient..

[Audio] Enterohepatic cycling of a drug is a process wherein the drug is transferred between the intestines and the liver. Initially the drug is taken up by the intestines and then metabolically adjusted in the liver. Afterward the modified drug is absorbed into the intestines and re-released into the bloodstream. This process allows the drug to create a longer-lasting effect in the body..

[Audio] Protein binding of drugs can be influenced by a range of factors such as pH the concentration of the drug concentration of the protein degree of ionisation presence of other drugs and presence of high-affinity binding sites. It is of great significance as it can have an impact on the effectiveness of the drug and its bioavailability..

[Audio] Drug clearance is a significant physiological process which facilitates improved drug bioavailability. It offers several main perks including permitting a steady rate of expulsion despite the existing elimination rate plus it offers a steady indication of drug concentration and the rate of drug elimination even if the rate is not consistent. This can enhance precision in drug dosing plus any other populace differences that may affect the drug's efficacy. Also clearance can be employed to enhance the patient's drug regimen and make sure the drug's safety and effectiveness..

[Audio] Particle size can have a major impact on the bioavailability of medications. It is linked to the dissolution rate solubility and permeability of the drug and can affect the speed of absorption and amount of drug that is absorbed via the digestive tissues. Smaller particles with higher solubility and faster dissolution rate will generally be more bioavailable than larger particles. The particle size of a drug can also manipulate the rate of absorption or bioavailability in the body giving particle size the capacity to increase the bioavailability of drugs..

[Audio] Nanosuspensions are a powerful way to enhance drug bioavailability. They involve suspending particles of a drug in a surfactant-containing solution with the particles typically having a size distribution below a micron often with an average particle size of 200-600 nanometers. A major benefit of this nanosuspension technology is its capability to accelerate drug dissolution due to the increased surface area of the particles. Examples of drugs utilising this technology include paclitaxel tarazepide and amphotericin B which are still being studied. It is a great tool to raise bioavailability and is significant for the author's company that provides data on enterohepatic cycling of drugs plus the advantages of drug clearance and particle size in boosting drug absorption..