AUGMENTIN 625mg DUO (BROAD SPECTRUM ANTIBIOTIC COMBINATION)

AUGMENTIN 625mg DUO (BROAD SPECTRUM ANTIBIOTIC COMBINATION).

INTRODUCTION. Augmentin 625 Duo is a broad spectrum antibiotic It belongs to class of beta lactam antibiotics Used for bacterial infections resistant to penicillin alone Contains Amoxicillin + Clavulanic acid Each film coated tablet contains: Amoxicillin Trihydrate which is equivalent to 500 mg Amoxicillin and Potassium Clavulanate which is equivalent to 125 mg Clavulanic acid Total: 625 mg per tablet.

CLASSIFICATION Pharmacological class: Amoxicillin- Beta lactam antibiotic (Penicillin group) Clavulanic acid – Beta lactamase inhibitor Therapeutic Class: Antibacterial / Antibiotic combination.

MECHANISM OF ACTION 1) Amoxicillin Inhibits bacterial cell wall synthesis Binds to penicillin binding proteins (PBPs)- weakens the wall and leads to bacterial lysis 2) Clavulanic Acid Inhibits Beta-lactamase enzymes produced by resistant bacteria. Protects amoxicillin from degradation and extends its spectrum..

SPECTRUM OF ACTIVITY Effective against: Gram positive – Streptococcus , Staphylococcus (non- MSRA) Gram negative – E.coli , H. influenza , Klebsiella Proteus , Neisserian Anaerobes – Bacteriodes spp..

PHARMACOKINETICS. PARAMETER Amoxicillin Clavulanic acid Absorption Rapid (oral) Rapid (oral) Bioavailability 70-90% 60% Metabolism Partial hepatic Hepatic Elimination Renal (mainly) Renal and hepatic Half-life ~1 hour ~1 hour.

INDICATIONS Used in the treatment of: Upper respiratory infections (sinusitis, otitis media) Lower respiratory infections (bronchitis, pneumonia) Urinary tract infections (UTIs) Skin and soft tissue infections Dental infections Bone and joint infections DOSAGE AND ADMINISTRATION Adults- One tablet (625mg) every 12 hours after meals Duration: 5-7 days (varies with type of infection type) Take after food to reduce gastric irritation.

ADVERSE EFFECTS COMMON – Nausea, vomiting, diarrhea, rash, urticarial SERIOUS (Rare) – Hypersentivity reactions (anaphylaxis) , Hepatic dysfunction (cholestatic jaundice), pseudomembranous colitis CONTRAINDICATIONS Do not use in: History of penicillin allergy Severe Hepatic Impairment Mononucleosis (Epstein- Barr infection) – causes rash.

DRUG INTERACTIONS Warfarin : Increases bleeding risk Methotrexate: Increases toxicity Allopurinol: Increases rash risk Oral contraceptives: Decreases efficacy PRECAUTIONS Take full course- don’t stop early Use cautiously in renal/hepatic impairment Probiotics may help prevent antibiotic-associated diarrhea. Avoid alcohol (to prevent stomach infection).

STORAGE AND STABILITY - Store below 35 degree C in a dry place. Protect from moisture Keep out of reach of children BRAND NAMES Common Brands (India): Augmentin 625 Duo – GSK Clavam 625 – Alkem Moxikind-CV 625 – Mankind Amoxyclav 625 - Abott.

SUMMARY. Feature Description Drug class Broad-spectrum Beta lactam antibiotics Components Amoxicillin + Clavulanic acid Mechanism Cell wall inhibition + Beta-lactamase inhibition Dosage 625 mg twice daily Uses Respiratory, urinary, skin, dental infections Adverse Effects GI upset, allergy, liver issues.

CASE EXAMPLE Case - A 35 year old male presents with sinusitis. Culture shows Beta-lactamase producing H. influenza Treatment – Augmentin 625 Duo BID for 7 days Outcome – Symptom relief within 3 days Combination therapy overcomes resistance.

CONCLUSION Augmentin 625 Duo- Powerful, well-tolerated antibiotic Effective for beta-lactamase producing bacterial infections Always use under medical supervision to prevent resistance RATIONAL USE OF ANTIBIOTICS = RESPONSIBLE PHARMACOTHERAPY.

THANK YOU “Antibiotic stewardship starts with awareness”.