Atropine and its analogues

Atropine and its analogues.

. Afropine pyoauc-å exfyac]eÅ from—BUladonna AKLloid amme *Can cross BBB C.LJS efGc*s P." .s+effæts Heckanism of achon + Alyopine is a CompUifive antaaonis+ OF muco-rinic vecepfoys (Afropne binds fotHlreceefors in -»cømpe}åive manner yece+fors I-nve a affæb Aho Hougvex, is prsene i} On ovey@me the of.

. Hedlanism au;on a. subjspgs of muscaijnic Non-Select;ve a4;on achon of cårop•ne on receebE is 31. Cßlock;tb adonJ 8 nbibfrs achcM Blocarp;.

. pharmacolzcd au;ons Y."oSis J Hddr;asis Diffe»ence coeen cixcßx m muc(e F phncf0Y.

. Pupil Iris Lens allowed to bulge Muscle like a sphincter on a bottom SUSpensory ligaments are sla:k Ciliary muscle Lens pulled thin Suspensory ligaments are pulled tight.

open angle Lens closed angle Lens. Drainage of aqueous humor in open-angle glaucoma.

maco\osA x.t;ons:. O. yeceetors Due do Inhibition of rry5gle Abenæ of miofic Qdion Ermenanf Is h3AYiasiS which \asf foy 7 _ Accomddwn fir fox VSioK wwæprse c I ijt Due b of yæeetoys in Cilia-y muscle of ciliNd muscle pullina CoÅyad;on df -he SugpenS0$ Lismenfs Hoe flåfenecl lens focd (enall of lens.

. Pbaxrnaco(zLcal aå;ons Afyopne a] SO Causes , _ 'tt't p yessc.u-e Duefo inhibåion of L jecep In PDQ@lIa.3 mqSde muscle PORS of Canal of sc%lemm of aqueous bumoY tm IOP 6 Lacy;md secu;ons Due of ors in, eel 'ld.

. Pbaxrnaco(zLcal aå;ons Afyopne a] SO Causes , _ 'tt't p yessc.u-e Duefo inhibåion of L jecep In PDQ@lIa.3 mqSde muscle PORS of Canal of sc%lemm of aqueous bumoY tm IOP 6 Lacy;md secu;ons Due of ors in, eel 'ld.

. Plaa.ymacde-l a40hS:. Cardiovasc,dær ssfem Afro ne prouce.$ divægit effects an C.VS QCCOYd; to ose Effed of a+rop•me on heaå t. doses of Kiah C tess }han o.b [2-5 m;] Ini+ia..( lächdca.rdla Due b in i if;on of OIS on pyezapf;c neurons Ach release -This inoeqse in ue fo inhi of YH and 2 recef-iors• Afrop;ne blocks 00 _2 to ACR from exa-t in hem-I Ide.

. Phaxmacoløoicd cv.s;. Afr •ne iraqces g r3 mecharusm Effed of inneyvåe TnKbfi,o yecp}oys in bjcxA vessels of f rauc and agao.rn;nd Viscera.

. c.v.s . Atropine a type of se vonl Causes G)fr affecÅ;nJ net atroÉne is 6J/fh rorrrn( hen-rd nan-tic' gecause induces rrok, atropine a m OAU] 9 pe Of hag l;Hle or ro effed on blmd vessels effed BJcuQ.

. Phaxmacøl*ica.l O. Gasfro-irdesf;na.l fya4 • recep}ors in GIT Of ærsåÅsis - Hot-oevey, atropine ve±) effechve anfBærrxJic acouse, enfe.yic nervous em i S (bnbol/aÅ Via Other I hormones ije.uxo Afropine doesMf affec_} production of ffCl used for b€otrnénf of.

. Pharm acol?icd AU;ons O. Respiro*oy Afropine inhb•, Eyecee}ovs in Bro Secans Atropine for fkUmen} of aabin,k h? yeceßojg on [JJ yecqf Ydeqse Reve-15%6 of induced of receptors.

Pbaxmaco(äicd ac*ions . Afropine b, in b)Qolclex,. of Relax of Bladder *inåers Sloa;jns vo'ld;nå Afropine inhibits tecep+oys in nexves fe.MV Secpe*i0hS.

ac.t;ohS 9. nexvoqs S em Yll yecee in of cehfers Hd\ucänoåions C) Delirium 10 rn Deeess•ton Ipna-l.as+;na seda*iøn Vomtf;ns Cenier.

. 7hexapU;c disease. Complemenf%J apprnc}l he.oårnenf of paykGrvson6 Dopamine ye3foye normal ±iajeen excåcutctd CAchJ oru inhjbiåOYd t Gffds paFßnøn3 parrine @. Due cf vornå;ns ev io Brain "c di#YdZS Fundus exami ion *necka in uveifis and iritis.

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GIT Gav erg ux;n disorders opioid $enf J Abuse morphine asociated fi•equeh4 u.yina.b) f;equenc; engyegis •tn chiLdæn UXOli+KiQS'tS ConfracÅi0Yl of uxe±exa.l gmcofh muscle Fau pasqye o.

-frtuapeå;c O. Pye-amsthet;c of resprai0Yd Cen}ev @ Bronchoa,biion ions > of vorni%r$ cen}ex CkÖlin Neyve poison•tns Zases Cholinesterase inh;båors toxic* O. Exce$ive swee*tindqced bd ecy;ne 60.) eek *nAS.

Afropine anu ues O. oph+ho.lrnå08d Scopolamine | 140moiY0f)i ne -3 )40dexOe (Jc)openfolote • vex Tiotropium Ions burnecliolifiium Hodexo-te >Tpvaåyopiurn [Atrovent' ac+;n.

Atyop;ne u.r;ha.r disorders;. > turipané NpT0'9ium CTrogpiKaP3 > Sol ifenac-in C Hicfonoym@J O. P».eeyahons POå4Gnsoæ ollSease Aenzfrop;ne Cc.oserd;n J > Benzhexol TiemoY$ induced Which •mAuceA bd.

Adverse efec*s:. mouth 2. Sanå edeg 3. low doses 0.2-2 uy;na.$ yeåehfioh 5. Censf;paåi0h 6. Res+lesshess Cchfusion Mod e.yåe closes HdluUhd;ohS 10. Deepesslon II. Collapse of and löxic Aoses > 10.

ions T,o.p 2. Pros}åjc Because, Afrop;ne induce reiggf;0Fl 3. gecause, [Ajyop;ne Slows.

Special afrepine on mice Afvopine inAuceg lhe When inejecåed info mice:- > Qes} lessness b-)o min > Runn'lno on {iptoes evechøn p" ne So Y)ame . A.XJ.S au;nå Arua.