Scene 1

. Afropine pyoauc-å exfyac]eÅ from—BUladonna AKLloid amme *Can cross BBB C.LJS efGc*s P." .s+effæts Heckanism of achon + Alyopine is a CompUifive antaaonis+ OF muco-rinic vecepfoys (Afropne binds fotHlreceefors in -»cømpe}åive manner yece+fors I-nve a affæb Aho Hougvex, is prsene i} On ovey@me the of. 

Scene 2

Afropine
pyoauc-å exfyac]eÅ from—BUladonna
AKLloid
amme *Can cross BBB C.LJS efGc*s
P." .s+effæts
Heckanism of achon
+ Alyopine is a CompUifive antaaonis+
OF muco-rinic vecepfoys
(Afropne binds fotHlreceefors in -»cømpe}åive
manner
yece+fors
I-nve a
affæb
Aho
Hougvex, is prsene
i} On ovey@me
the of

. Hedlanism au;on a. subjspgs of muscaijnic Non-Select;ve a4;on achon of cårop•ne on receebE is 31. Cßlock;tb adonJ 8 nbibfrs achcM Blocarp;. 

Scene 3

Hedlanism au;on
a. subjspgs of muscaijnic
Non-Select;ve
a4;on
achon of cårop•ne on receebE is
31.
Cßlock;tb adonJ
8 nbibfrs achcM
Blocarp;

. pharmacolzcd au;ons Y."oSis J Hddr;asis Diffe»ence coeen cixcßx m muc(e F phncf0Y. 

Scene 4

pharmacolzcd au;ons
Y."oSis J Hddr;asis
Diffe»ence coeen
cixcßx
m
muc(e
F phncf0Y

. Pupil Iris Lens allowed to bulge Muscle like a sphincter on a bottom SUSpensory ligaments are sla:k Ciliary muscle Lens pulled thin Suspensory ligaments are pulled tight. 

Scene 5

Pupil
Iris
Lens allowed to bulge
Muscle
like a sphincter on a bottom SUSpensory ligaments
are sla:k
Ciliary muscle
Lens pulled thin
Suspensory ligaments
are pulled tight

muscle
Ciliary
Cornea
Iris
ligaments
Canal ut
Sch

open angle Lens closed angle Lens. Drainage of aqueous humor in open-angle glaucoma. 

Scene 6

Drainage of aqueous humor in open-angle glaucoma

Drainage of aqueous humor in mydriasis and angle-closure glaucoma

maco\osA x.t;ons:. O. yeceetors Due do Inhibition of rry5gle Abenæ of miofic Qdion Ermenanf Is h3AYiasiS which \asf foy 7 _ Accomddwn fir fox VSioK wwæprse c I ijt Due b of yæeetoys in Cilia-y muscle of ciliNd muscle pullina CoÅyad;on df -he SugpenS0$ Lismenfs Hoe flåfenecl lens focd (enall of lens. 

Scene 7

maco\osA x.t;ons:.
O. yeceetors
Due do Inhibition of
rry5gle
Abenæ of miofic
Qdion
Ermenanf
Is h3AYiasiS
which
\asf foy 7 _
Accomddwn
fir fox VSioK
wwæprse c
I ijt
Due b of
yæeetoys in
Cilia-y muscle
of
ciliNd muscle
pullina
CoÅyad;on df
-he SugpenS0$
Lismenfs
Hoe flåfenecl
lens
focd (enall
of lens

. Pbaxrnaco(zLcal aå;ons Afyopne a] SO Causes , _ 'tt't p yessc.u-e Duefo inhibåion of L jecep In PDQ@lIa.3 mqSde muscle PORS of Canal of sc%lemm of aqueous bumoY tm IOP 6 Lacy;md secu;ons Due of ors in, eel 'ld. 

Scene 8

Pbaxrnaco(zLcal aå;ons
Afyopne a] SO Causes , _
'tt't
p yessc.u-e
Duefo inhibåion of
L jecep In
PDQ@lIa.3
mqSde
muscle
PORS
of Canal of sc%lemm
of
aqueous bumoY
tm IOP
6
Lacy;md
secu;ons
Due of
ors in,
eel 'ld

Scene 9

. Plaa.ymacde-l a40hS:. Cardiovasc,dær ssfem Afro ne prouce.$ divægit effects an C.VS QCCOYd; to ose Effed of a+rop•me on heaå t. doses of Kiah C tess }han o.b [2-5 m;] Ini+ia..( lächdca.rdla Due b in i if;on of OIS on pyezapf;c neurons Ach release -This inoeqse in ue fo inhi of YH and 2 recef-iors• Afrop;ne blocks 00 _2 to ACR from exa-t in hem-I Ide. 

Scene 10

Plaa.ymacde-l a40hS:.
Cardiovasc,dær ssfem
Afro ne prouce.$ divægit effects an C.VS QCCOYd;
to ose
Effed of a+rop•me on heaå t.
doses of Kiah
C tess }han o.b
[2-5 m;]
Ini+ia..( lächdca.rdla
Due b in i if;on of
OIS on
pyezapf;c
neurons
Ach release
-This inoeqse in
ue fo inhi of
YH and 2 recef-iors•
Afrop;ne blocks
00 _2 to
ACR from
exa-t in
hem-I Ide

. Phaxmacoløoicd cv.s;. Afr •ne iraqces g r3 mecharusm Effed of inneyvåe TnKbfi,o yecp}oys in bjcxA vessels of f rauc and agao.rn;nd Viscera. 

Scene 11

Phaxmacoløoicd
cv.s;.
Afr •ne iraqces
g r3 mecharusm
Effed of inneyvåe
TnKbfi,o yecp}oys in bjcxA vessels
of f rauc and agao.rn;nd Viscera

. c.v.s . Atropine a type of se vonl Causes G)fr affecÅ;nJ net atroÉne is 6J/fh rorrrn( hen-rd nan-tic' gecause induces rrok, atropine a m OAU] 9 pe Of hag l;Hle or ro effed on blmd vessels effed BJcuQ. 

Scene 12

c.v.s
. Atropine a type of
se vonl Causes
G)fr affecÅ;nJ
net atroÉne is
6J/fh rorrrn( hen-rd nan-tic'
gecause induces
rrok, atropine
a m OAU] 9 pe Of hag l;Hle or ro effed
on blmd vessels
effed
BJcuQ

. Phaxmacøl*ica.l O. Gasfro-irdesf;na.l fya4 • recep}ors in GIT Of ærsåÅsis - Hot-oevey, atropine ve±) effechve anfBærrxJic acouse, enfe.yic nervous em i S (bnbol/aÅ Via Other I hormones ije.uxo Afropine doesMf affec_} production of ffCl used for b€otrnénf of. 

Scene 13

Phaxmacøl*ica.l
O. Gasfro-irdesf;na.l fya4
• recep}ors in GIT
Of
ærsåÅsis
- Hot-oevey, atropine ve±) effechve anfBærrxJic
acouse, enfe.yic nervous
em
i S (bnbol/aÅ Via Other I hormones
ije.uxo
Afropine doesMf affec_} production of ffCl
used for
b€otrnénf of

. Pharm acol?icd AU;ons O. Respiro*oy Afropine inhb•, Eyecee}ovs in Bro Secans Atropine for fkUmen} of aabin,k h? yeceßojg on [JJ yecqf Ydeqse Reve-15%6 of induced of receptors. 

Scene 14

Pharm acol?icd AU;ons
O. Respiro*oy
Afropine inhb•, Eyecee}ovs in
Bro
Secans
Atropine for fkUmen} of
aabin,k
h? yeceßojg on
[JJ yecqf
Ydeqse
Reve-15%6 of
induced
of receptors

Pbaxmaco(äicd ac*ions . Afropine b, in b)Qolclex,. of Relax of Bladder *inåers Sloa;jns vo'ld;nå Afropine inhibits tecep+oys in nexves fe.MV Secpe*i0hS. 

Scene 15

Pbaxmaco(äicd ac*ions
. Afropine b, in b)Qolclex,.
of
Relax of
Bladder *inåers
Sloa;jns vo'ld;nå
Afropine inhibits tecep+oys in
nexves
fe.MV
Secpe*i0hS

ac.t;ohS 9. nexvoqs S em Yll yecee in of cehfers Hd\ucänoåions C) Delirium 10 rn Deeess•ton Ipna-l.as+;na seda*iøn Vomtf;ns Cenier. 

Scene 16

ac.t;ohS
9. nexvoqs S em
Yll yecee in
of
cehfers
Hd\ucänoåions
C)
Delirium
10 rn
Deeess•ton
Ipna-l.as+;na
seda*iøn
Vomtf;ns
Cenier

. 7hexapU;c disease. Complemenf%J apprnc}l he.oårnenf of paykGrvson6 Dopamine ye3foye normal ±iajeen excåcutctd CAchJ oru inhjbiåOYd t Gffds paFßnøn3 parrine @. Due cf vornå;ns ev io Brain "c di#YdZS Fundus exami ion *necka in uveifis and iritis. 

Scene 17

7hexapU;c
disease. Complemenf%J apprnc}l
he.oårnenf of paykGrvson6
Dopamine
ye3foye normal
±iajeen excåcutctd CAchJ
oru inhjbiåOYd t
Gffds
paFßnøn3
parrine
@. Due cf
vornå;ns ev io Brain
"c di#YdZS
Fundus
exami ion
*necka
in uveifis and
iritis

9. Respira*o disorders Chvø%ie disease AsåKma Because,fhe bpexachve neuxd reflex viq nave ocoxolid Because, Nose p:åienfs experience reflex SAN AVN Ad pexaåive Ca.rof;4 Sinus reflexes Because, }hcse pa-+,enfs rnQd experience fo_infness clue +0 in vespnse +0 o-n the neck.. 

Scene 18

9. Respira*o disorders
Chvø%ie
disease
AsåKma
Because,fhe bpexachve neuxd
reflex
viq nave
ocoxolid
Because, Nose p:åienfs
experience reflex
SAN
AVN
Ad pexaåive
Ca.rof;4
Sinus reflexes
Because, }hcse pa-+,enfs
rnQd experience fo_infness
clue +0
in vespnse +0
o-n the neck.

GIT Gav erg ux;n disorders opioid $enf J Abuse morphine asociated fi•equeh4 u.yina.b) f;equenc; engyegis •tn chiLdæn UXOli+KiQS'tS ConfracÅi0Yl of uxe±exa.l gmcofh muscle Fau pasqye o. 

Scene 19

GIT
Gav erg
ux;n disorders
opioid $enf
J Abuse
morphine
asociated
fi•equeh4
u.yina.b)
f;equenc;
engyegis
•tn chiLdæn
UXOli+KiQS'tS
ConfracÅi0Yl
of uxe±exa.l
gmcofh muscle
Fau
pasqye o

-frtuapeå;c O. Pye-amsthet;c of resprai0Yd Cen}ev @ Bronchoa,biion ions > of vorni%r$ cen}ex CkÖlin Neyve poison•tns Zases Cholinesterase inh;båors toxic* O. Exce$ive swee*tindqced bd ecy;ne 60.) eek *nAS. 

Scene 20

-frtuapeå;c
O. Pye-amsthet;c
of resprai0Yd Cen}ev @
Bronchoa,biion
ions
> of vorni%r$ cen}ex
CkÖlin
Neyve
poison•tns Zases
Cholinesterase
inh;båors
toxic*
O. Exce$ive swee*tindqced bd ecy;ne
60.) eek *nAS

Afropine anu ues O. oph+ho.lrnå08d Scopolamine | 140moiY0f)i ne -3 )40dexOe (Jc)openfolote • vex Tiotropium Ions burnecliolifiium Hodexo-te >Tpvaåyopiurn [Atrovent' ac+;n. 

Scene 21

Afropine anu ues
O. oph+ho.lrnå08d
Scopolamine |
140moiY0f)i ne
-3 )40dexOe
(Jc)openfolote
• vex
Tiotropium Ions
burnecliolifiium
Hodexo-te
>Tpvaåyopiurn [Atrovent'
ac+;n

Atyop;ne u.r;ha.r disorders;. > turipané NpT0'9ium CTrogpiKaP3 > Sol ifenac-in C Hicfonoym@J O. P».eeyahons POå4Gnsoæ ollSease Aenzfrop;ne Cc.oserd;n J > Benzhexol TiemoY$ induced Which •mAuceA bd. 

Scene 22

Atyop;ne
u.r;ha.r disorders;.
> turipané
NpT0'9ium CTrogpiKaP3
> Sol ifenac-in
C Hicfonoym@J
O. P».eeyahons POå4Gnsoæ ollSease
Aenzfrop;ne Cc.oserd;n J
> Benzhexol
TiemoY$
induced
Which
•mAuceA bd

Adverse efec*s:. mouth 2. Sanå edeg 3. low doses 0.2-2 uy;na.$ yeåehfioh 5. Censf;paåi0h 6. Res+lesshess Cchfusion Mod e.yåe closes HdluUhd;ohS 10. Deepesslon II. Collapse of and löxic Aoses > 10. 

Scene 23

Adverse efec*s:.
mouth
2. Sanå edeg
3. low doses
0.2-2
uy;na.$ yeåehfioh
5. Censf;paåi0h
6. Res+lesshess
Cchfusion
Mod e.yåe closes
HdluUhd;ohS
10. Deepesslon
II. Collapse of
and
löxic Aoses
> 10

ions T,o.p 2. Pros}åjc Because, Afrop;ne induce reiggf;0Fl 3. gecause, [Ajyop;ne Slows. 

Scene 24

ions
T,o.p
2. Pros}åjc Because, Afrop;ne
induce reiggf;0Fl
3. gecause, [Ajyop;ne Slows

Special afrepine on mice Afvopine inAuceg lhe When inejecåed info mice:- > Qes} lessness b-)o min > Runn'lno on {iptoes evechøn p" ne So Y)ame . A.XJ.S au;nå Arua. 

Scene 25

Special afrepine on mice
Afvopine inAuceg lhe When inejecåed
info mice:-
> Qes} lessness
b-)o min
> Runn'lno on {iptoes
evechøn
p" ne
So Y)ame .
A.XJ.S au;nå Arua

Atropine and its analogues