[Audio] Lets talk about the anti hypertensive drugs.. 

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[Audio] . Most influences on blood pressure can be understood in terms of their effect on cardiac output,systemic vascular resistance,. Cardiac output is the product of stroke volume and heart rate. Stroke volume is influenced by the end diastolic volume which is influenced by blood volume , cardiac contractility and afterload. So In the short-term, the greater the blood volume, the higher the cardiac output.. 

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Mean Arterial Pressure
Cardiac Output
Parasympathetic Sy*hetic Venous return
Total Peripheral Resistance
Olar radius
Metblic
Sympathqic
norepinephrine
epinephrine

[Audio] Drug can lower BP by Dilating arterioles resistance Or Dilating venous capacitance Or Reduce the cardiac contractility Or Reduce HR Or Depletion of body sodium. 

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Dilating  arterioles  resistance – nitrates ,  Ca  Channel blockers , alpha 1 blockers  Dilating venous  capacitance -  Reduce the cardiac  contractility – beta blockers Reduce  HR – beta blockers Depletion of body  sodium – drugs act on RAAS

[Audio] There are few types. Betablockers , calcium channel blockers , diuretics , alpha 1 blocekers, adrenergic drugs , and drug act on RAAS are them. I will talk separate videos about diuretics and calciumchannel blockers and drug act on Renin Angiotensin System. 

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Anti  hypersentive  drugs Beta blockers Selective  Non selective Renin inhibitor Diuretics Drug act on RAAS ACE inhibitor ARBs CA inhibitor Osmotic diuretics loop diuretics Thiazide diuretics K+ sparing diuretics Alpha 1 blockers Adrenergic  drug Calcium channel blockers

[Audio] Beta blockers can be divided to selective and non selective. Beta 1 selective blockers again can be divided to pure and partial selective beta blockers. Pure beta blockers like atenolol , metoprolol, bisopeolol reduces cardiac out put and reduce blood pressure. Labetalol and carvedilol are non selective beta blockers which reduces Cardia outuput and systemic vascular resistence which leads to reduce blood pressure. 

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Beta blocker Selective (B1) Atenolol Metoprolol Non selective Bisoprolol   Labetalol Carvedilol

[Audio] Prazosin , Doxazosin are alpha 1 blocker which blocks the alpha 1 receptors on vascular epithelium and resuces the systemic vascular resistance . Advaerse drud reaction of these drug is postural hypertension.. 

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[Audio] Centrally acting adrenergic drug are Clonidine and Methyldopa which decrease the acetyl choline release and reduce cardiac output and systemic vascular resistance to decrease blood pressure.. 

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Centrally acting ↓Ach release ↓ CO & SVR

[Audio] Thank you lets see you in antihypertensive drug part 2. 

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Anti Hypertensive Drug


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Lets talk about the anti hypertensive drugs.

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Most influences on blood pressure can be understood in terms of their effect on cardiac output,systemic vascular resistance,

Cardiac output is the product of stroke volume and heart rate

Stroke volume is influenced by  the end diastolic volume which is influenced by blood volume , cardiac contractility

So In the short-term, the greater the blood volume, the higher the cardiac output.

Betablockers , calcium channel blockers ,  diuretics ,  alpha 1 blocekers, adrenergic drugs ,  and drug act on RAAS are them

I will talk separate videos about diuretics and calciumchannel blockers and drug act on Renin Angiotensin System

Beta blockers can be divided to selective and non selective

Beta 1 selective blockers again can be divided to pure and partial selective beta blockers

Pure beta blockers like atenolol , metoprolol, bisopeolol reduces cardiac out put and reduce blood pressure

Labetalol and carvedilol are non selective beta blockers which reduces Cardia outuput and systemic vascular resistence which leads to reduce blood pressure

Prazosin , Doxazosin are alpha 1 blocker which blocks the alpha 1 receptors on vascular epithelium and resuces the systemic vascular resistance

Advaerse drud reaction of these drug is postural hypertension.

Centrally acting adrenergic drug are Clonidine and Methyldopa which decrease the acetyl choline release and reduce cardiac output and systemic vascular resistance  to decrease blood pressure.

Thank you lets see you in antihypertensive drug part 2