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Drugs_Pregnancy_Labour_Puerperium.pdf > ppt.com ERGOT DERIVATIVES Ergot alkaloids are either natural or semi synthetic Preparations Ergometrine- 0.25mg/ 0.5mg ampoules & 0.5-1mg tablets Methergine - 0.2 mg ampoules & 0.5-1mg tablets Syntometrine Ergometrine - 0.5 mg+ syntocinon 5.0 units ampoules. Methergine QErgometrine & Methergine can be used parenterally or orally. As the drug produces titanic uterine contractions, it should only be used after delivery of the anterior shoulder or following delivery of baby. • It should not be used in induction of labor or abortion. •Syntometrine should always be administered IM Mode of Action Ergometrine acts directly on the myometrium. It stimulates uterine contractions & decreases bleeding..
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Indications Therapeutic 1. To stop the atonic uterine bleeding following delivery, abortion/ expulsion of hydatidiform mole Prophylactic 1. As a prophylaxis against excessive hemorrhage , " nay be administered after the delivery of the anterior shoulder with crowing / following delivery of baby. Contraindications 1. Suspected plural pregnancy 2. Organic cardiac disease 3. Severe Pre-eclampsia & Eclampsia fppt.com Adverse effects 1. Rise of BP due to vasoconstriction action 2. Prolonged use in puerperium may interfere by decrease concentration of prolactin & gangrene of toes due to vasoconstriction. Dosage and routes of administration •For active management of 3' stage of labour -0.2mg(iamp) to be given IM. •For control of atonic PPH -1amp slowly over 60 seconds, may be repeated after 2hrs. •For excessive lochia and subinvolution-1 Tablet(0.125mg)TDS for 3 days..
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Adverse effects 1. Rise of BP due to vasoconstriction action 2. Prolonged use in puerperium may interfere by decrease concentration of prolactin & gangrene of toes due to vasoconstriction. Dosage and routes of administration •For active management of 3r' stage of labour -0.2mg(iamp) to be given IM. •For control of atonic PPH -1amp slowly over 60 seconds, may be repeated after 2hrs. •For excessive lochia and subinvolution-1 Tablet(0.125mg)TDS for 3 days. fppt.com Nursing considerations 1. Assess patient BP, pulse, respiration, signs of hemorrhage 2. Administer Orally/IM deep, have emergency cart readily available 3. Evaluate for decrease blood loss 4. Advised patient to report for increased blood loss, abdominal cramps, headache, sweating, nausea, vomiting/ dyspnea.