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By Khokha. Dyslipiderrnia.
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Lipoproteins. Lipid Protein Lipoprotein.
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Lipoprotein = lipid transport.
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Causes of Hyperlipidemia Lifestyle Diabetes Mellitus Kidney disease Pregnancy Hypothyroidism Genetic Alcohol Dyslipidemia Drugs- Thiazides, Cyclosporin, Glucocorticoids, Beta Blockers..
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Protein Phospholipid Cholesterol Triglyceride A. A lipoprotein 0000 0 Chylomicron — VI-DL HDL B. The variety Of lipoproteins Blood Lipids Serum Triglycerides • VLDL • CHYLOMICRONS Serum Cholesterol • LDL (Bad, 77.5%) • HDL (Good, 17.5%) IDL (Neutral, 5%).
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1-chylomicron mainly T.G carry lipid from intestine to liver 2-VLDL mainly T.G from liver to blood 3-ILDL half cholesterol half T.G 4-LDL mainly cholesterol bad cholesterol 5-HDL from tissues to liver good cholesterol.
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6/1/2022. Life Cycle of Cholesterol-carrying LIPOPROTEINS Liver produces LIPOPROTEINS LDL Lipoprotein Molecule Triglyceride (fat) VLDL fat ce Ils TRIGLYCERIDE Muscle burn TRIGLYCERIDE.
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0.95 1 .006 1 .02 1 .06 1.10 1.20 HDL o 5 o 10 IDL LDL 20 VLDL 40 Diameter, nm Chylomicron remnants Chylomicron 60 80 1 ooo.
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Antihyperlipedemic drugs. Hyperlipidemia SINGLE USE ONLY.
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Classification. Statins Niacin Fibrates Bile acid resins, Ezetimibe.
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BILE ACID-BINDING RESINS (CHOLESTYRAMINE) 1-Bind to bile acids in the intestine decrease cholesterol and T.G absorption 2-prevent their absorption and . preventing the recycling of bile acids, bile acid-binding resins divert hepatic cholesterol to synthesis of new bile acids, thereby reducing the amount of cholesterol..
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Mechanism of action. ÙتÙجة بØØ« اÙصÙر ع٠âªbile binnding resinâ¬â.
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Side effect 1-GIT disturbance (steatorrhea) 2-decrease absorption of fat soluble vitamins 3-cholesterol gall stones.
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EZETIMIBE.
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Mechanism of action Selective inhibition of cholesterol absorption both 1-exogenous (dietary ) 2-endogenous (biliary).
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Preparations (HMG CO A Reductase inhibitors) atorvastatin, simvastatin.
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Mechanism of action Inhibition of HMG-co A reductase decrease so, inhibit synthesis of cholesterol in liver.