Fifth lab.

Fifth lab..

Contents. timeline.

Kapron Antihemorrhagic. timeline. Tranexamic acid.

I. Tranexamic acid Kapron ampoule® [500 mg /5 ml].

1- Identification Spectral data: 1 H-NMR spectrum:.

Assignment Multiplicity Chemical shift Letter Cyclohexyl -H m (9H) 1-1.8 a NH 2 s (2H) 2 b CH m (1H) 2.2 c CH 2 d (2H) 2.4 d COOH s (1H) 12.1 e.

Principle:. Addition of known excess of 0.1 M NaOH and back titration of excess unreacted NaOH with 0.1 M HCl ..

Principle:. Assay:. [ Formol titration]. Tranexamic acid + n-formalin.

2-Purity tests: [1] L.T. for Halides [chloride]. Test Standard 5 ml sample+ 10 ml distilled water 10 ml standard Cl + 5 ml distilled water 1 ml dil. HNO 3 1 ml AgNO 3 Mix and compare the white turbidity.

.eu!zmneN. timeline. Chlorpromazine.

Chlorpromazine Hydrochloride (B.P. 2012). Actions and Uses : Typical antipsychotic..

1-Identification a- Spectral data:. IR spectrum:.

a. b. b. c. d. 1 H-NMR spectrum. e. e. a. b. c. d.

Letter Chemical shift Multiplicity Assignment a 1.6 m(2H) CH 2 b 2.3 s(6H) 2 CH 3 c 2.4 t(2H) CH 2 d 3.1 t(2H) CH 2 e 6.5-7 m(7H) Ar -H.

Molecular ion peak (M + )= 318. Mass spectrum.

2. Assay. Chlorpromazine is a weak base , assayed quantitatively by Non-aqueous titration using std. perchloric acid and methyl orange as indicator..

Procedure for Chlorpromazine HCl powder:. In beaker: take 10 ml Chlorpromazine HCl sample + 20 ml dist water, mix well. Titrate against 0.1 M NaOH. Determine end point potentiometrically..

Calculations:. 1 ml of 0.1 M NaOH = 35.53 mg of chlorpromazine.

Procedure for Chlorpromazine HCl tablets: 1. Powder 1 tablet ( Neurazine ® 100 mg ), triturate the powder with 10 ml of absolute ethanol, add about 100 ml of 0.1 M HCl and shake for 15 minutes. 2. Add sufficient 0.1 M HCl to produce 250 ml , filter. ( Solution A ) 3. Dilute 10 ml of the filtrate to 100 ml with 0.1 M HCl. ( Solution B ) 4. Further dilution of 10 ml to 100 ml with the same solvent. ( Solution C ) 5.Measure the absorbance of the resulting solution at the maximum at 254 nm . 6.Calculate the content of C 17 H 19 ClN 2 S.HCl taking 915 as the value of A(1%, 1 cm) at the maximum at 254 nm..

Calculations:. 1 Neurazin tablet (100 mg). 250 ml.

timeline. NMR Revision Sheets.

8 peaks. 9 peaks. 7 peaks. Encircle the correct structure number with the given results in the given table: (1) IH-NMR chart then interpret your CF3 (2).

Assignment Multiplicity ( No of H s ) Chemical shift (ppm) Letter 2 C H 2 m ( 4H ) 1.5 a N H 2 s (2H) 2 b C H 2 t (2H) 2.7 c NH 2 -C H 2 t (2H) 2.8 d C H 3 s (3H) 3.3 e.

f. sheet no.2:. Diagram Description automatically generated.

Assignment Multiplicity ( No of H s ) Chemical shift (ppm) Letter C H 2 m (2H) 1.5 a Piperazine- Hs s (8H) 2.3 b Piperazine-C H 2 -CH 2 t (2H) 2.4 c Piperazine-C H 2 -CH 2 -OH t (2H) 2.6 d C H 2 -OH t (2H) 3.4 e.

No triplet and quartet peaks for ethyl CH 3 -CH 2 in Spectrum So it’s Not Structure 2.

Assignment Multiplicity ( No of H s ) Chemical shift (ppm) Letter C H 3 s (3H) 2.2 a Piperazinyl- Hs s (8H) 2.3 b N-C H 2 t (2H) 2.5 c C H 2 t (2H) 3.2 d Aromatic- Hs m (7H) 6.8 - 7.3 e.

No NH 2 exchangeable protons in spectrum Not Structure 2.

Assignment Multiplicity ( No of H s ) Chemical shift (ppm) Letter C H 2 q (2H) 2 a 2 C H 3 s (6H) 2.3 b N-C H 2 t (2H) 2.4 c Olefinic- H t (1H) 6 d Aromatic- Hs m (7H) 6.8-7.2 e.

Thank you.