Pharmaceutical calculations

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Concentrations of Pharmaceutical Preparations. vehicle Product ingredient.

. Volume  1 L or 1000 mL أساسي في المعادلة. Required volume  L or mL المطلوب تحضيره.

Summary. 1g/100g 1:100 10000 ppm 1%. .

Examples. Suppose we prepared a solution by mixing 8 g of KCl (solute) with 42 g of water (solvent), calculate % w/w (mass percent) of KCl solution Solute wt = 8 g Solvent wt = 42 g Product wt = 8+42= 50 g ???? % w/w  ? g solute / 100 g product 8  50 X  100 X= 100 * 8 /50= 16 %w/w.

Examples. A solution is prepared with 15 g of Na 2 CO 3 and 235 g of H 2 O. What is the mass percent (m/m) of Na 2 CO 3 in the solution Solute wt = 15 g Solvent wt = 235 g Product wt = 15+235= 250 g ???? % m/m  ? g solute / 100 g product 15  250 X  100 X= 100 * 15 /250 = 6 % m/m.

Examples. .

Examples. ℞ Sulfur 3% salicylic acid 3% white petrolatum q.s. 80 g Find out the amount of sulfur required to fill the above prescription? The total wt of the product = 80 g Sulfur is 3% of the whole weight of the product 3  100 X  80 X= 80 * 3 / 100 = 2.4 g.

Practice. How many grams of Dextrose are required to prepare 5% of 500 mL solution? How much Lidocaine is required to prepare 30 mL of solution of Lidocaine with concentration (1: 1000)? If 250 mg of Cefazolin powder are diluted with water up to the 250 cc mark, what is the % w/v of drug in the final solution ? How much clotrimazole is present in 60 gm of 0.5% cream? An ointment contains 12 g of drug completed to 100 g with cream base. What is the percentage concentration? Express 1 : 500 NaOH solution as a percentage. Express 900 mg of sodium chloride made up to 100 mL with water as a percentage. A morphine sulfate injection contains 10 mg/ mL. What is the percentage concentration?.

Answer. 1- 25 g 2- 30 mg 3- 0.1% w/v 4- 0.3 g = 300 mg 5- 12% w/w 6- 0.2% w/v 7- 0.9% w/v 8- 1% w/v.