Basic Life Science Training. Introduction of Pharmaceutical Manufacturing. 

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Introduction of Pharmaceutical Manufacturing

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Objectives. Close-up of purple cells. In this presentation we will discuss the following: Pharmaceutical Supply Chain 3 types of manufacturing processes Common Pharmaceutical manufacturing processes. 

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In this presentation we will discuss the following: Pharmaceutical Supply Chain  3 types of manufacturing processes Common Pharmaceutical manufacturing processes

Advanced Manufacturing Tech Solutions (AMTSOL) 2022

Pharmaceutical Supply Chain. Advanced Manufacturing Tech Solutions (AMTSOL) 2022. 

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Pharma Supply chain is  essential in delivering cures to patients Manufacturing Supplier Raw Material Patient Pharmacy/Hospital Distribution Warehouse

The importance of Pharma Supply Chain. Patient Access to Medicines Product Integrity and Safety Regulatory Compliance Efficiency and Cost-Effectiveness Product Authentication and Anti-Counterfeiting Emergency Preparedness. 

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Patient Access to Medicines Product Integrity and Safety Regulatory Compliance Efficiency and Cost-Effectiveness Product Authentication and Anti-Counterfeiting Emergency Preparedness

Supply chain resilience is a priority for the pharmaceutical sector

What is Manufacturer?. Microscopic view of a suspended bubble-like material with water in it. 

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Microscopic view of a suspended bubble-like material with water in it

A manufacturer is a person or company that produces finished goods from raw materials by using various tools, equipment, and processes, and then sells the goods to consumers, wholesalers, distributors, retailers, or to other manufacturers for the production of more complex goods.
 Source: Corporate finance institute

Types of Manufacturing processes. Advanced Manufacturing Tech Solutions (AMTSOL) 2022. 

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Discreet Manufacturing Batch Process Manufacturing Products comprised of parts that can be touched, counted… Parts can be broken down and disposed at the end of the product lifecycle Use Bill of Material Frequent setup and changeover Example: Equipment, Machinery, Automotive, Medical device process that involves a sequence of steps followed in a specific order. set-up costs are initially less expensive drug companies can produce specific amounts of a certain product and then adjust their manufacturing priorities according to the changing demands of the market Continuous Manufacturing the flow of a single unit of product between every step of the process without any break in time, substance or extend. more time-efficient, reduces energy needs, helps to increase productivity and reduces the amount of overall waste pasta production, tomato sauce and juice production, ice cream production, mayonnaise production

Introduction of API. Api pharma companies Overview, Market Dynamics & According to study Active Pharmaceutical Ingredients Market size is Projected to reach 263.8 Bn by 2025 | Medgadget. 

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Api pharma companies Overview, Market Dynamics & According to study Active  Pharmaceutical Ingredients Market size is Projected to reach 263.8 Bn by  2025 | Medgadget

All drugs are made up of two core components: ​​ the API (Active Pharmaceutical Ingredient), which is the central ingredient to produce the effects, ​​ and the excipients, the substances other than the drug that helps deliver the medication to your system.​​ A leading manufacturer of APIs is TEVA Pharmaceuticals ​​ Most API manufacturers are located in Asia, particularly in India and China​​ Contract Manufacturing Organization​

API Typical Manufacturing Process. Advanced Manufacturing Tech Solutions (AMTSOL) 2022. 

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Introduction of API Starting material  Production of intermediates Isolation and Purification Physical processing and packaging Raw Material A Raw Material B Reactor Filtration Crystallization Centrifuge Drying Milling Packaging

Tableting Manufacturing. To formulate strong and hard tablets that are uniform in weight and in drug content, stable over the long period of time.​ Process steps include​ Weighing​ Milling​ Mixing​ Granulation​ Drying​ Compaction​ Coating and Packaging​. 

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To formulate strong and hard tablets that are uniform in weight and in drug content, stable over the long period of time.​ Process steps include​ Weighing​ Milling​ Mixing​ Granulation​ Drying​ Compaction​ Coating and Packaging​

[image] How Tablets Are Manufactured Thomas Processing

Pharmaceutical Tableting Manufacturing process. Image result for tableting process. 

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Pharmaceutical Tableting Manufacturing process

Biomanufacturing​. Biotechnology is technology based on biology, using living cell and genetic manipulation to produce products to improve life and health​ Usually are large, complex molecules;​ Examples of biologics include blood or blood products, gene therapies, vaccines, and cell therapies.. 

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Biotechnology is technology based on biology, using living cell and genetic manipulation to produce products to improve life and health​ Usually are large, complex molecules;​ Examples of biologics include blood or blood products, gene therapies, vaccines, and cell therapies.

Biomanufacturing Process. Advanced Manufacturing Tech Solutions (AMTSOL) 2022. 

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Upstream Processing Downstream Processing





 Upstream Processing Fermentation Harvesting/ Recovery Separation Purification Filling Media is prepared, cells are nurtured and grown Cells/crude product are taken from media Product is isolated and purified Product is filled into containers for use e.g. bulk filled, for later Fill Finish processing

Cell & Gene Therapy​. Insertion of normal DNA directly into cells to correct a genetic defect. The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease.​ https://www.youtube.com/watch?v=IQa4qJ8xcf0. 

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Insertion of normal DNA directly into cells to correct a genetic defect. The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease.​
 https://www.youtube.com/watch?v=IQa4qJ8xcf0

Summary. [image] Microscopic view of cells. Pharma Supply Chain is important in ensuring the ready supply of medicine to patients worldwide Manufacturing play a key role in supply chain where medicines are produced with high quality and safety standard 3 types of manufacturing: discreet, batch and continuous Common pharmaceutical manufacturing processes include API, Tableting, Biologics and Cell & Gene Therapy. 

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Pharma Supply Chain is important in ensuring the ready supply of medicine to patients worldwide Manufacturing play a key role in supply chain where medicines are produced with high quality and safety standard 3 types of manufacturing: discreet, batch and continuous Common pharmaceutical manufacturing processes include API, Tableting, Biologics and Cell & Gene Therapy

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 A manufacturer is a person or company that produces finished goods from raw materials by using various tools, equipment, and processes, and then sells the goods to consumers, wholesalers, distributors, retailers, or to other manufacturers for the production of more complex goods.
 Source: Corporate finance institute

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 All drugs are made up of two core components: ​​ the API (Active Pharmaceutical Ingredient), which is the central ingredient to produce the effects, ​​ and the excipients, the substances other than the drug that helps deliver the medication to your system.​​ A leading manufacturer of APIs is TEVA Pharmaceuticals ​​ Most API manufacturers are located in Asia, particularly in India and China​​ Contract Manufacturing Organization​


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 Insertion of normal DNA directly into cells to correct a genetic defect. The treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for a disease.​
 https://www.youtube.com/watch?v=IQa4qJ8xcf0

Introduction of Pharmaceutical Manufacturing

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